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Specific Adhesion and Molecular Recognition

JPEG The quantitative determination of reaction or association rate coefficients is a major issue in the field of chemical physics. In a certain number of cases, these rates depend on the time it takes for the reactive species to occupy a specific mutual spatial and orientational configuration that enables subsequent association or reaction step. Such rates are known to be limited by diffusion. Biochemistry offers numerous examples of multi-molecular association (formation of large long-lived complexes) where the mutual diffusion movement of the intervening species is expected to be a key factor controlling the association dynamics.

Moreover, the assumption of viscous hydrodynamics is reasonable for large molecules. The relative simplicity of the association kinetics in homogeneous solutions is lost when one of the reactive species is immobilized near a surface, and deriving the correct association rate in this situation is a challenging issue, even though the volume kon kinetic coefficient is known.

Articles in this section

  • Influence of colloidal rotational dynamics on the rate of specific adhesion

    A team from ESPCI Paris, managed to turn a super- paramagnetic colloidal beads system into a powerful analytical tool for studying the specific adhesion kinetics promoted by ligand-receptors pairs bounded to surfaces. The contribution of the Membrane and Microforces team to this breakthrough (...)

  • Influence of softness on molecular recognition

    Figure 1: Conjecture: the tendency of the lipids in a membrane to phase separate should favour non-selective adhesion.
    In , we introduced a simple model of soft interacting patterned objects. It is shown that if properly designed, soft interacting partners can display a non-monotonic affinity (...)

  • Sliding Tethered Ligands

    Figure 1: The SlidTetherLig project has a double ambition: i) to deliver a new family of biotechnological tools for building soft nanointerfaces and ii) to open new perspectives in stealth liposome technology by self-assembling a new type of stealth liposomal vector for drug delivery. (...)

  • Adhesion and polymer dynamics

    We have quantified polymer chain dynamics and the kinetics and spatial range of tethered ligand-receptor binding. A Science paper shows that the efficiency of strong tethered binding depends on its rare extended conformations. Using the reaction-diffusion formalism, we also show that the range (...)

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