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Author (up) Bauer, M.; Kekicheff, P.; Iss, J.; Fajolles, C.; Charitat, T.; Daillant, J.; Marques, C.M. doi  openurl
  Title Sliding tethered ligands add topological interactions to the toolbox of ligand-receptor design Type Journal Article
  Year 2015 Publication Nature Communications Abbreviated Journal  
  Volume 6 Issue Pages  
  Keywords  
  Abstract Adhesion in the biological realm is mediated by specific lock-and-key interactions between ligand-receptor pairs. These complementary moieties are ubiquitously anchored to substrates by tethers that control the interaction range and the mobility of the ligands and receptors, thus tuning the kinetics and strength of the binding events. Here we add sliding anchoring to the toolbox of ligand-receptor design by developing a family of tethered ligands for which the spacer can slide at the anchoring point. Our results show that this additional sliding degree of freedom changes the nature of the adhesive contact by extending the spatial range over which binding may sustain a significant force. By introducing sliding tethered ligands with self-regulating length, this work paves the way for the development of versatile and reusable bio-adhesive substrates with potential applications for drug delivery and tissue engineering.  
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  Series Volume Series Issue Edition  
  ISSN 2041-1723 ISBN Medium mcube  
  Area Expedition Conference  
  Notes Times Cited: 0Marques, Carlos/B-2322-2010; Charitat, Thierry/M-6146-2014Marques, Carlos/0000-0002-3952-0498; Charitat, Thierry/0000-0003-3167-64950 Approved no  
  Call Number Admin @ benzerara @ Bauer2015 Serial 13830  
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