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Author (up) Zahouani, S.; Chaumont, A.; Senger, B.; Boulmedais, F.; Schaaf, P.; Jierry, L.; Lavalle, P. openurl 
  Title Stretch-Induced Helical Conformations in Poly(L-lysine)/Hyaluronic Acid Multilayers Type Journal Article
  Year 2016 Publication Acs Applied Materials & Interfaces Abbreviated Journal ACS Appl. Mater. Interfaces  
  Volume 8 Issue 24 Pages 14958-14965  
  Keywords polyelectrolyte multilayers; mechanoresponsive materials; circular dichroism; molecular dynamics; secondary structure  
  Abstract We investigate the effect of stretching on the secondary structure of cross-linked poly(L-lysine)/hyaluronic acid (PLL/HA) multilayers. We show that stretching these films induces changes in the secondary structure of PLL chains. Our results suggest that not only alpha- but also 3(10)-helices might form in the film under stretching. Such 3(10)-helices have never been observed for PLL so far. These changes of the secondary structure of PLL are reversible, i.e., when returning to the nonstretched state one recovers the initial film structure. Using molecular dynamics simulations of chains composed of 20 L-lysine residues (PLL20), we find that these chains never adokt a helical conformation in water. In contrast, when the end-to-end distance of the chains is restrained to values smaller than the mean end-to-end distance of free chains, a distance domain rarely explored by the free chains, helical conformations become accessible. Moreover, the formation of not only alpha- but also 3(10)-helices is predicted by the simulations. These results suggest that the change of the end-to-end distance of PLL chains in the stretched film is at the origin of the helix formation.  
  Address [Zahouani, Sarah; Senger, Bernard; Schaaf, Pierre; Lavalle, Philippe] INSERM, U1121, 11 Rue Humann, F-67085 Strasbourg, France, Email: schaaf@unistra.fr;  
  Corporate Author Thesis  
  Publisher Amer Chemical Soc Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1944-8244 ISBN Medium  
  Area Expedition Conference  
  Notes WOS:000378584800008 Approved no  
  Call Number Admin @ benzerara @ Serial 14034  
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