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Author (up) Knopf-Marques, H.; Singh, S.; Htwe, S.S.; Wolfova, L.; Buffa, R.; Bacharouche, J.; Francius, G.; Voegel, J.C.; Schaaf, P.; Ghaemmaghami, A.M.; Vrana, N.E.; Lavalle, P. openurl 
  Title Immunomodulation with Self-Crosslinked Polyelectrolyte Multilayer-Based Coatings Type Journal Article
  Year 2016 Publication Biomacromolecules Abbreviated Journal Biomacromolecules  
  Volume 17 Issue 6 Pages 2189-2198  
  Abstract This study aims to design an optimal polyelectrolyte multilayer film of poly-TAySine (PLL) and hyalurohic acid (HA) as an anti-inflammatory cytoldrie release system in order to decrease the implant failure due to any immune reactions. The chemical :modification of the HA with aldehyde moieties allows self-cross-linking of the film and an improvement in the mechanical properties. of the film. The cross-linking of the film and the release of immunomodulatory cytokine (IL-4) stimulate the differentiation of primary human inonocytes seeded on the films into pro-healing macrophages phenotype. This induces the production of anti-inflammatory cytokines-(IL1-RA and CCL18) and- the decrease of pro inflammatory cytokines secreted (IL-12, TNF-alpha; and IL-1 beta). Moreover, we demonstrate that cross-linking PLL/HA film using HA-aldehyde is already effective by itself to limit inflammatory processes. Finally, this functionalized self-cross-linked PLL/HA-aldehyde films constitutes an innovative and- efficient candidate for imrnunomodulation of any kind of implants of various architecture and properties.  
  Address [Knopf-Marques, Helena; Voegel, Jean-Claude; Schaaf, Pierre; Vrana, Nihal Engin; Lavalle, Philippe] INSERM, UMR 1121, 11 Rue Humann, F-67085 Strasbourg, France, Email:  
  Corporate Author Thesis  
  Publisher Amer Chemical Soc Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1525-7797 ISBN Medium  
  Area Expedition Conference  
  Notes WOS:000377924800030 Approved no  
  Call Number Admin @ benzerara @ Serial 14040  
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