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Author (up) Weinberger, A.; Walter, V.; MacEwan, S.R.; Schmatko, T.; Muller, P.; Schroder, A.P.; Chilkoti, A.; Marques, C.M. url  doi
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  Title Cargo self-assembly rescues affinity of cell-penetrating peptides to lipid membranes Type Journal Article
  Year 2017 Publication Scientific Reports Abbreviated Journal Sci Rep  
  Volume 7 Issue Pages 43963  
  Keywords  
  Abstract Although cationic cell-penetrating peptides (CPPs) are able to bind to cell membranes, thus promoting cell internalization by active pathways, attachment of cargo molecules to CPPs invariably reduces their cellular uptake. We show here that CPP binding to lipid bilayers, a simple model of the cell membrane, can be recovered by designing cargo molecules that self-assemble into spherical micelles and increase the local interfacial density of CPP on the surface of the cargo. Experiments performed on model giant unilamellar vesicles under a confocal laser scanning microscope show that a family of thermally responsive elastin-like polypeptides that exhibit temperature-triggered micellization can promote temperature triggered attachment of the micelles to membranes, thus rescuing by self-assembly the cargo-induced loss of the CPP affinity to bio-membranes.  
  Address Universite de Strasbourg, CNRS, ICS UPR 22, F-67000 Strasbourg, France  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 2045-2322 ISBN Medium mcube  
  Area Expedition Conference  
  Notes PMID:28262825 Approved no  
  Call Number ICS mcube @ thierry.charitat @ Serial 14048  
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