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Author (up) Amalian, J.-A.; Trinh, T.T.; Lutz, J.-F.; Charles, L. url  doi
  Title MS/MS Digital Readout: Analysis of Binary Information Encoded in the Monomer Sequences of Poly(triazole amide)s Type Journal Article
  Year 2016 Publication Analytical Chemistry Abbreviated Journal  
  Volume 88 Issue 7 Pages 3715-3722  
  Abstract Tandem mass spectrometry was evaluated as a reliable sequencing methodology to read codes encrypted in monodisperse sequence-coded oligo(triazole amide)s. The studied oligomers were composed of monomers containing a triazole ring, a short ethylene oxide segment, and an amide group as well as a short alkyl chain (propyl or isobutyl) which defined the 0/1 molecular binary code. Using electrospray ionization, oligo(triazole amide)s were best ionized as protonated molecules and were observed to adopt a single charge state, suggesting that adducted protons were located on every other monomer unit. Upon collisional activation, cleavages of the amide bond and of one ether bond were observed to proceed in each monomer, yielding two sets of complementary product ions. Distribution of protons over the precursor structure was found to remain unchanged upon activation, allowing charge state to be anticipated for product ions in the four series and hence facilitating their assignment for a straightforward characterization of any encoded oligo(triazole amide)s.  
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  Notes Pmid: 26950162 Approved no  
  Call Number Admin @ benzerara @ doi:10.1021/acs.analchem.5b04537 Serial 14232  
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