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Author (up) Kluzek, M.; Schmutz, M.; Marques, C.M.; Thalmann, F. url  doi
  Title Kinetic evolution of DOPC lipid bilayers exposed to alpha-cyclodextrins Type Journal Article
  Year 2018 Publication Soft Matter Abbreviated Journal Soft Matter  
  Volume 14 Issue 28 Pages 5800-5810  
  Abstract Cyclodextrins are cyclic oligosaccharides capable of forming inclusion complexes with a variety of molecules, and as such have been recognized as a pharmaceutical and biotechnological asset. Cyclodextrins are known to interact with the components of cell membranes, and this correlates with a significant degree of cytotoxicity. In this work, we report on the mechanism of degradation of a model dioleoyl-phosphatidylcholine (DOPC) bilayer exposed to a solution with increasing concentrations of alpha-cyclodextrins. By combining optical fluorescence microscopy and quartz-crystal microbalance experiments, we study the evolution of supported lipid bilayers (SLBs) and giant unilamellar vesicles (GUVs). The rate of lipid removal is found to display a strong nonlinear dependence on the cyclodextrin concentration. A mechanism involving lipid aggregates is proposed.  
  Address Universite de Strasbourg, CNRS, Institut Charles Sadron, UPR022, 23 rue du Loess, 67034 Strasbourg Cedex, France.  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1744-683X ISBN Medium mcube  
  Area Expedition Conference  
  Notes PMID:29947414 Approved no  
  Call Number ICS mcube @ thierry.charitat @ Serial 14351  
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