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Author (up) Kluzek, M.; Schmutz, M.; Marques, C.M.; Thalmann, F. url  doi
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  Title Kinetic evolution of DOPC lipid bilayers exposed to alpha-cyclodextrins Type Journal Article
  Year 2018 Publication Soft Matter Abbreviated Journal Soft Matter  
  Volume 14 Issue 28 Pages 5800-5810  
  Keywords  
  Abstract Cyclodextrins are cyclic oligosaccharides capable of forming inclusion complexes with a variety of molecules, and as such have been recognized as a pharmaceutical and biotechnological asset. Cyclodextrins are known to interact with the components of cell membranes, and this correlates with a significant degree of cytotoxicity. In this work, we report on the mechanism of degradation of a model dioleoyl-phosphatidylcholine (DOPC) bilayer exposed to a solution with increasing concentrations of alpha-cyclodextrins. By combining optical fluorescence microscopy and quartz-crystal microbalance experiments, we study the evolution of supported lipid bilayers (SLBs) and giant unilamellar vesicles (GUVs). The rate of lipid removal is found to display a strong nonlinear dependence on the cyclodextrin concentration. A mechanism involving lipid aggregates is proposed.  
  Address Universite de Strasbourg, CNRS, Institut Charles Sadron, UPR022, 23 rue du Loess, 67034 Strasbourg Cedex, France. monika.kluzek@weizmann.ac.il fabrice.thalmann@ics-cnrs.unistra.fr  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1744-683X ISBN Medium mcube  
  Area Expedition Conference  
  Notes PMID:29947414 Approved no  
  Call Number ICS mcube @ thierry.charitat @ Serial 14351  
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