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Author (up) Bacellar, I.O.L.; Baptista, M.S.; Junqueira, H.C.; Wainwright, M.; Thalmann, F.; Marques, C.M.; Schroder, A.P. url  doi
  Title Permeability of DOPC bilayers under photoinduced oxidation: Sensitivity to photosensitizer Type Journal Article
  Year 2018 Publication Biochimica et Biophysica Acta Abbreviated Journal Biochim Biophys Acta  
  Volume Issue Pages  
  Keywords Lipid photooxidation; Membrane permeabilization; Model membrane; Phenothiazinium photosensitizers; Pore formation  
  Abstract The modification of lipid bilayer permeability is one of the most striking yet poorly understood physical transformations that follow photoinduced lipid oxidation. We have recently proposed that the increase of permeability of photooxidized 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) bilayers is controlled by the time required by the oxidized lipid species to diffuse and aggregate into pores. Here we further probe this mechanism by studying photosensitization of DOPC membranes by methylene blue (MB) and DO15, a more hydrophobic phenothiazinium photosensitizer, under different irradiation powers. Our results not only reveal the interplay between the production rate and the diffusion of the oxidized lipids, but highlight also the importance of photosensitizer localization in the kinetics of oxidized membrane permeability.  
  Address Institut Charles Sadron, Universite de Strasbourg, CNRS UP22, 23 rue du Loess, 67200 Strasbourg, France. Electronic address:  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0006-3002 ISBN Medium mcube  
  Area Expedition Conference  
  Notes PMID:29886032 Approved no  
  Call Number ICS mcube @ thierry.charitat @ Serial 14352  
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