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Author  |
Morandi, M.I.; Sommer, M.; Kluzek, M.; Thalmann, F.; Schroder, A.P.; Marques, C.M. |
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Title |
DPPC Bilayers in Solutions of High Sucrose Content |
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Journal Article |
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Year |
2018 |
Publication |
Biophysical Journal |
Abbreviated Journal |
Biophys J |
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Volume |
114 |
Issue |
9 |
Pages |
2165-2173 |
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Abstract |
The properties of lipid bilayers in sucrose solutions have been intensely scrutinized over recent decades because of the importance of sugars in the field of biopreservation. However, a consensus has not yet been formed on the mechanisms of sugar-lipid interaction. Here, we present a study on the effect of sucrose on 1,2-dipalmitoyl-sn-glycero-3-phosphocholine bilayers that combines calorimetry, spectral fluorimetry, and optical microscopy. Intriguingly, our results show a significant decrease in the transition enthalpy but only a minor shift in the transition temperature. Our observations can be quantitatively accounted for by a thermodynamic model that assumes partial delayed melting induced by sucrose adsorption at the membrane interface. |
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Address |
Universite de Strasbourg, CNRS, Institut Charles Sadron, UPR022, Strasbourg Cedex, France. Electronic address: marques@unistra.fr |
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Language |
English |
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ISSN |
0006-3495 |
ISBN |
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Medium |
mcube |
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Notes |
PMID:29742409 |
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Call Number |
ICS mcube @ thierry.charitat @ |
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14353 |
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