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Author (up) Morandi, M.I.; Sommer, M.; Kluzek, M.; Thalmann, F.; Schroder, A.P.; Marques, C.M. url  doi
openurl 
  Title DPPC Bilayers in Solutions of High Sucrose Content Type Journal Article
  Year 2018 Publication Biophysical Journal Abbreviated Journal Biophys J  
  Volume 114 Issue 9 Pages 2165-2173  
  Keywords  
  Abstract The properties of lipid bilayers in sucrose solutions have been intensely scrutinized over recent decades because of the importance of sugars in the field of biopreservation. However, a consensus has not yet been formed on the mechanisms of sugar-lipid interaction. Here, we present a study on the effect of sucrose on 1,2-dipalmitoyl-sn-glycero-3-phosphocholine bilayers that combines calorimetry, spectral fluorimetry, and optical microscopy. Intriguingly, our results show a significant decrease in the transition enthalpy but only a minor shift in the transition temperature. Our observations can be quantitatively accounted for by a thermodynamic model that assumes partial delayed melting induced by sucrose adsorption at the membrane interface.  
  Address Universite de Strasbourg, CNRS, Institut Charles Sadron, UPR022, Strasbourg Cedex, France. Electronic address: marques@unistra.fr  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0006-3495 ISBN Medium mcube  
  Area Expedition Conference  
  Notes PMID:29742409 Approved no  
  Call Number ICS mcube @ thierry.charitat @ Serial 14353  
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