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Membranes and Microforces

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Mcube team web site

The team “M3: Membranes and microforces” came into being in January 2005. Its members share a common interest in complex interfaces in general and self-assembled phospholipid systems in particular. They study the behaviour of these systems from the physical, experimental and theoretical points of view and dispose of a common experimental expertise, encompassing notably micromanipulation techniques and the measurement of microforces.

One of the originalities of our research is that it associates a strong experimental component with important efforts in the field of modelling. We develop and use a large number of experimental techniques specifically adapted for our systems, some of these methods being unique. We probe the structure and dynamics of interfaces on a level ranging from the nanometre to the millimetre scale, combining techniques of light or X-ray diffraction and optical microscopy. Finally, we analyze the response of these systems to applied forces, using methods allowing the measurement of forces in confined situations and micromanipulation.

The work of the group is divided into three areas of research:

  • Lipid bilayers: giant vesicles and deposited membranes
  • Surfaces: direct measurement of surface forces and kinetics of adhesion
  • Systems out of equilibrium morphology, mechanisms and dynamics

The principal collaborations of the group M3 include: LIONS (CEA Saclay, France), Sejong University (Seoul, South Korea), Constance University (Germany), Sao-Paulo University (Brazil) and the University of California UC Davis (USA).

Detailed information on the team, its members, their research activities and their publications may be found on the M3 web site, at the address http://www.ics-cnrs.unistra.fr/Mcube/.

Key words: surface force apparatus (SFA), fluorescence recovery after photobleaching (FRAP), large instruments (X-ray and neutron diffraction), fluorescence and confocal microscopy, reflection interference contrast microscopy (RICM), micropipette manipulation, electroformation of vesicles, supported phospholipid bilayers, controlled adhesion, polymer-membrane interactions.

Members of the team:

Basler Marc more informations here
Benazieb Othmène more informations here
Charitat Thierry more informations here
Marques Carlos more informations here
Mukhina Tetiana more informations here
Muller Pierre more informations here
Salamone Salvatore more informations here
Schmatko Tatiana more informations here
Schröder André more informations here
Stocco Antonio more informations here
Thalmann Fabrice more informations here
Wolf Jean more informations here


Blachon, F., Harb, F., Munteanu, B., Piednoir, A., Fulcrand, R., Charitat, T., et al. (2017). Nanoroughness Strongly Impacts Lipid Mobility in Supported Membranes. Langmuir, 33(9), 2444–2453.
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Weinberger, A., Walter, V., MacEwan, S. R., Schmatko, T., Muller, P., Schroder, A. P., et al. (2017). Cargo self-assembly rescues affinity of cell-penetrating peptides to lipid membranes. Sci Rep, 7, 43963.
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Guo, Y., Baulin, V. A., & Thalmann, F. (2016). Peroxidised phospholipid bilayers: insight from coarse-grained molecular dynamics simulations. Soft Matter, 12(1), 263–271.
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Hemmerle, A., Fragneto, G., Daillant, J., & Charitat, T. (2016). Reduction in Tension and Stiffening of Lipid Membranes in an Electric Field Revealed by X-Ray Scattering. Phys Rev Lett, 116(22), 228101.
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Micheletto, Y. M. S., Marques, C. M., Silveira, N. P. da, & Schroder, A. P. (2016). Electroformation of Giant Unilamellar Vesicles: Investigating Vesicle Fusion versus Bulge Merging. Langmuir, 32(32), 8123–8130.
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Micheletto, Y. M. S., Moro, C. F., Lopes, F. C., Ligabue-Braun, R., Martinelli, A. H. S., Marques, C. M., et al. (2016). Interaction of jack bean (Canavalia ensiformis) urease and a derived peptide with lipid vesicles. Colloids Surf B Biointerfaces, 145, 576–585.
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Aoki, P. H. B., Schroder, A. P., Constantino, C. J. L., & Marques, C. M. (2015). Bioadhesive giant vesicles for monitoring hydroperoxidation in lipid membranes. Soft Matter, 11(30), 5995–5998.
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Bauer, M., Kekicheff, P., Iss, J., Fajolles, C., Charitat, T., Daillant, J., et al. (2015). Sliding tethered ligands add topological interactions to the toolbox of ligand-receptor design. Nature Communications, 6.
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Gromer, A., Nassar, M., Thalmann, F., Hebraud, P., & Holl, Y. (2015). Simulation of Latex Film Formation Using a Cell Model in Real Space: Vertical Drying. Langmuir, 31(40), 10983–10994.
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Hemmerle, A., Froehlicher, G., Bergeron, V., Charitat, T., & Farago, J. (2015). Worm-like instability of a vibrated sessile drop. Epl, 111(2).
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Korobko, A. V., Marques, C. M., Schoeps, M., Schaelder, V., Wiesner, U., & Mendes, E. (2015). Dielectric discontinuity in equilibrium block copolymer micelles. Soft Matter, 11(36), 7081–7085.
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Mukherji, D., Marques, C. M., Stuehn, T., & Kremer, K. (2015). Co-non-solvency: Mean-field polymer theory does not describe polymer collapse transition in a mixture of two competing good solvents. Journal of Chemical Physics, 142(11).
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Weinberger, A., Tanasescu, R., Stefaniu, C., Fedotenko, I. A., Favarger, F., Ishikawa, T., et al. (2015). Bilayer Properties of 1,3-Diamidophospholipids. Langmuir, 31(6), 1879–1884.
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Wolff, J., Komura, S., & Andelman, D. (2015). Budding of domains in mixed bilayer membranes. Physical Review E, 91(1).
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Arranja, A., Schroder, A. P., Schmutz, M., Waton, G., Schosseler, F., & Mendes, E. (2014). Cytotoxicity and internalization of Pluronic micelles stabilized by core cross-linking. Journal of Controlled Release, 196, 87–95.
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